<!DOCTYPE html>
<style>
.grid {
  display: inline-grid-lanes;
  grid-template-columns: 50px 100px auto;
  grid-gap: 10px;
  border: 1px solid;
}
item { background: silver; margin: 5px; }
</style>

<div class="grid">
  <item style="border:10px solid">1</item>
  <item>2</item>
  <item>3</item>
  <item style="height:50px">4</item>
  <item>5</item>
  <item>6</item>
</div>
